副教授

杜毅

职称:副教授

学历:博士

邮箱:yidu@ahmu.edu.cn

地址:合肥市瑶海区唐河路，安徽医科大学东校区，弘毅东楼303

个人简介
2022.07 - 现在 安徽医科大学生命科学学院，校聘副教授
2016.09 - 2022.06 中国科学技术大学，硕博连读，博士
2012.09 - 2016.07 西北大学，学士
科研领域
本课题组主要利用功能核酸搭建用于诊断和治疗的新工具以实现生物学和医学领域的应用，目前的研究重点包括：1、基于变构核酸的生物标志物可视化检测； 2、基于核酸分子器件的靶向蛋白质降解。
代表性成果

1. Hangsheng Gong, Yihan Zhang, Yuan Xue, Bowen Fang, Yuting Li, Xudong Zhu*, Yi Du*, Pai Peng*. NETosis-Inspired Cell Surface-Constrained Framework Nucleic Acids Traps (FNATs) for Cascaded Extracellular Recognition and Cellular Behavior Modulation. Angew. Chem. Int. Ed. 2024, e202319908.
2. Yi Du, Qiwei Wang, Lili Shi, Tao Li. G-quadruplex-Proximized Aptamers (G4PA) Efficiently Targeting to Cell-Surface Transferrin Receptors for Targeted Cargo Delivery. Nano.Lett., 2022, 15, 6328-6333.
3. Yi Du#, Pai Peng#, Tao Li*. DNA Logic Operations in Living Cells Utilizing Lysosome-Recognizing Framework Nucleic Acid Nanodevices for Subcellular Imaging. ACS Nano 2019, 13, 5778-5784.
4. Yi Du, Pai Peng, Tao Li*. Logic circuit controlled multi-responsive branched DNA scaffolds. Chem. Commun. 2018, 54, 6132–6135.
5. Pai Peng#, Yi Du#, Jiao Zheng, Huihui Wang, Tao Li*. Reconfigurable Bioinspired Framework Nucleic Acid Nanoplatform Dynamically Manipulated in Living Cells for Subcellular Imaging. Angew. Chem. Int. Ed. 2019, 58, 1648–1653.
6. Jiao Zheng, Yi Du, Huihui Wang, Pai Peng, Lili Shi, Tao Li*. Ultrastable Bimolecular G-quadruplexes Programmed DNA Nanoassemblies for Reconfigurable Biomimetic DNAzymes. ACS Nano 2019, 13, 11947–11954.
7. Pai Peng, Yi Du, Tao Li*. DNA Nanodevices Monitored with Fluorogenic Looped-Out 2-Aminopurine. Analyst 2018, 143, 1268–1273.
8. Pai Peng, Yi Du, Yudie Sun, Shuangna Liu, Lan Mi, Tao Li*. Probing Propeller-Like Loops of DNA G-quadruplexes with Looped-Out 2-Aminopurine for Label-Free Switchable Molecular Sensing. Analyst 2018, 143, 3814–3820.
9. Lili Shi, Pai Peng, Yi Du, Tao Li*. Programmable I-Motif DNA Folding Topology for a pH-Switched Reversible Molecular Sensing Device. Nucleic Acids Res. 2017, 45, 4306–4314.
10. Huihui Wang, Pai Peng, Qiwei Wang, Yi Du, Zhijin Tian, Tao Li*. Environment-Recognizing DNA-Computation Circuits for the Intracellular Transport of Molecular Payloads for mRNA Imaging. Angew. Chem. Int. Ed. 2020, 59, 6099–6107.
11. Pai Peng, Qiwei Wang, Yi Du, Huihui Wang, Lili Shi, Tao Li*. Extracellular Ion-Responsive Logic Sensors Utilizing DNA Dimeric Nanoassemblies on Cell Surface and Application to Boosting AS1411 Internalization. Anal. Chem. 2020, 92, 9273–9280. 

研究课题
1. 国家自然科学基金青年项目，22407002 ，2025/01-2027/12，主持；
2. 安徽省高等学校科学研究项目重点项目，2024AH050714 ，2025/01-2026/12，主持；
3. 安徽医科大学引进人才项目，0801043201，2022/07-2027/07，主持；

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